Collaborative practices for medicinal chemistry research across the big pharma and not-for-profit interface


Drug Discovery Today 2014, article in press
There have been many publications in recent years on the topic of drug discovery collaborations between industry and academic groups. The majority discuss plans and strategies and nothing is ever heard again from the authors with respect to the success of the project or otherwise. This article written by scientists from Astra Zeneca, Medical Research Council Technology and Cancer Research Technology is refreshingly different. It describes a model used by the teams in successful collaborations, highlights the factors which contributed to the success and describes potential improvements which could be considered for future work.

In establishing the working model the authors looked to address key issues which had hampered previous collaborative models. They highlight two key issues as (a) the need for academics to publish work early (largely riven by funding bodies) which has the potential to compromise intellectual property and (b) unbalanced contributions from the parties involved – with industrial groups often acting as coordinators/directors and the academics performing the practical work.

With the issues in mind the groups established collaborative working models from the outset which were actively designed to address these issues and included initiatives which include (a) the initial planning and drafting of research agreement actively involved scientists from each organisation thus addressing conflicting demands at the outset and these agreements contained clear definitions of milestones and ownership of each contributing organisation (b) to create a single project team with members from all the partner organisations which communicates regularly and uses a common language, this overcomes differences in terminology between partner organisations and leads to efficient working (c) the design and use of an electronic data sharing tool to data to be shared in real time across the entire project. The tool contained all of the information necessary to allow team members to rapidly assimilate date and make decisions based on it.

The authors end by suggesting some additional initiatives which could be incorporated in future projects to improve efficiency further still. These suggestions include (a) Further improving face to face communication by considering staff exchanges or secondments and (b) As IT packages were a crucial factor in the success of the projects to ensure that these are set up and all staff trained in their use at the very start of the project, something which the authors could have been set up more efficiently in their experience to date and led to some early problems.
This is an excellent article and any group considering embarking on a collaborative drug discovery exercise is encouraged to read it.

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